Xiyan Xiang

BACKGROUND: Colonic polyposis, which is a risk factor for colorectal cancer (CRC), can be driven by a pathogenic variant in a polyposis gene. However, in many cases germline genetic testing is negative, leaving the cause of the polyposis unknown…

BACKGROUND: Diets high in animal fat and low in plant fiber increase colorectal cancer (CRC) risk, while diets high in fiber, but low in animal fat, are protective. Bacteria present in the colon produce beneficial and harmful metabolites from our diets…

BACKGROUND: Obesity and pro-inflammatory alterations of the gut microbiome are risk factors for gastrointestinal (GI) cancers, including liver cancer (HCC). Dysregulated TGF-β signaling through Smad3 and βII-Spectrin and loss of CEACAM1 activity are implicated in fatty liver disease…

BACKGROUND: Colon cancer is rising in younger people, with a potential link to diet and the gut microbiome. Yet, it is unclear how signaling pathways, host-microbe interactions and metabolites regulate cancer development…