Walter Koltun

Background: Resolution of intestinal inflammation requires well-tuned communication between the immune compartment and the epithelium, carried out primarily via secreted mediators. The expression of these mediators is predominantly regulated by the transcription factor NF-κB…

Background: Mesenteric fat wrapping around the intestinal wall, so called ‘creeping fat’ (CF), is spatially linked with stricture formation in Crohn’s disease (CD)…

Paneth cells reside at the bottom of the crypts in the small intestine and are crucial for maintaining homeostasis of the epithelium by engendering host protection from enteric pathogens…

BACKGROUND The prevalence of chronic liver disease is increasing but it remains underdiagnosed, with frequent late presentation. Development in early adulthood is likely to associate with higher lifetime cirrhosis risk but early identification of asymptomatic patients can prove challenging…

INTRODUCTION: Crohn’s Disease (CD), one of the major forms of inflammatory bowel disease (IBD), involves genetic and environmental factors and currently has no cure. Fibrosis is strongly associated with CD, has no pharmacological treatment, and often requires surgical intervention…

BACKGROUND: Ulcerative colitis (UC) is a chronic multifactorial disease with limited management options. Hyperactivation of Janus kinase (JAK) signaling is implicated in the pathogenesis of UC…