Thomas Ma

Phosphatase and tensin homolog (PTEN) is a lipid phosphatase, while its protein phosphatase activity is being suggested. Since the classical role of PTEN as a tumor suppressor is unclear in the gut, we hypothesize PTEN’s alternative function in regulating gut homeostasis…

BACKGROUND A defective gastrointestinal epithelial tight junction (TJ) barrier has been implicated as a key pathogenic factor in inflammatory bowel diseases (IBD) and other gut inflammatory conditions…

Background: Mesenteric fat wrapping around the intestinal wall, so called ‘creeping fat’ (CF), is spatially linked with stricture formation in Crohn’s disease (CD)…

This session will cover the pathogenic and non-pathogenic constituents of the gut microbiome that induce local and systemic inflammatory response and play an important role in disease development…

Paneth cells reside at the bottom of the crypts in the small intestine and are crucial for maintaining homeostasis of the epithelium by engendering host protection from enteric pathogens…

BACKGROUND: Dysfunctional intestinal tight junctions (TJ) barrier is a key pathogenetic factor of inflammatory bowel diseases…