Tatiana Karakasheva

BACKGROUND: Enterochromaffin cells (ECs) are specialized gastrointestinal (GI) epithelial cells that transduce luminal forces and chemicals into release of signal molecules including serotonin (5-HT) to alter GI function including mucosal ion transport…

BACKGROUND: Eosinophilic esophagitis (EoE) is an allergic inflammatory disorder in which chronic inflammation leads the development of fibrosis and stricture formation. Unfortunately, the mechanisms underlying fibrosis remain elusive…

BACKGROUND: Eosinophilic esophagitis (EoE) is a chronic immune-mediated inflammatory disorder characterized by persistent inflammation, decreased esophageal distensibility, and esophageal stricture…

BACKGROUND: Eosinophilic esophagitis (EoE) is a chronic inflammatory disorder of the esophagus characterized by eosinophilic inflammation as well as impaired epithelial differentiation and barrier integrity…

INTRODUCTION: Intestinal epithelial stem cells (ISCs) are essential for maintenance of the epithelial barrier, yet their role in Crohn’s disease (CD) is not understood…