Steven McAninch

Background: Resolution of intestinal inflammation requires well-tuned communication between the immune compartment and the epithelium, carried out primarily via secreted mediators. The expression of these mediators is predominantly regulated by the transcription factor NF-κB…

INTRODUCTION: Crohn’s Disease (CD), one of the major forms of inflammatory bowel disease (IBD), involves genetic and environmental factors and currently has no cure. Fibrosis is strongly associated with CD, has no pharmacological treatment, and often requires surgical intervention…

BACKGROUND: Ulcerative colitis (UC) is a chronic multifactorial disease with limited management options. Hyperactivation of Janus kinase (JAK) signaling is implicated in the pathogenesis of UC…