Sima Fansa

BACKGROUND: Sound evidence support the effectiveness of the transoral outlet reduction (TORe) with full-thickness endoscopic suturing (FTS) or argon plasma coagulation (APC) alone to address post-RYGB weight regain…

Background: Transoral outlet reduction endoscopy (TORe) has been shown to be effective in managing weight regain after Roux-en-Y gastric bypass (RYGB), as has the glucagon-like peptide-1 agonist, liraglutide. However, the effect of adjunctive liraglutide after TORe has yet to be assessed…

BACKGROUND: Our phenotype-guided approach to antiobesity medications is associated with greater weight loss compared to the obesity medicine standard of care…

INTRODUCTION: Enteroendocrine cells (EEC) secrete satiety hormones Glucagon-like peptide 1 (GLP-1) and Peptide YY (PYY) in response to luminal content through nutrient-sensing GPCRs…

INTRODUCTION: A phenotype-tailored lifestyle intervention (PLI) has shown superior outcomes when compared to a standard lifestyle intervention (SLI) in a 12-week trial (PMID: 37007741). However, phenotype testing for obesity is time-consuming, expensive, and not widely accessible…