Sidhartha Sinha

BACKGROUND: Cancer is a major cause of morbidity and mortality in persons with inflammatory bowel disease (IBD). We evaluated temporal trends and relative risks of intestinal and extra-intestinal cancers among persons with IBD and matched controls…

BACKGROUND: Primary sclerosing cholangitis (PSC) is a progressive, cholestatic liver disease without medical cure, that confers a significantly elevated risk of malignancy, acute cholangitis and cirrhosis. Approximately 2-7% of patients with inflammatory bowel disease (IBD) will develop PSC…

BACKGROUND: Loss of immune tolerance to commensal gut bacteria plays a critical role in the pathogenesis of inflammatory bowel disease (IBD). Prior studies have demonstrated that immunoglobulin (Ig) binding to the gut microbiota is altered in IBD and associated with disease activity…

BACKGROUND: Novel noninvasive methods for evaluating disease activity in patients with inflammatory bowel disease (IBD) are needed to reduce patient burden of traditional assessments, which can involve lab sample collections for blood and stool tests, bowel preparation, and additional appointments…