Shengxiang Sun

Background: Canonical autophagy is a multi-step process and involves initiation (mediated by _Fip200_,_ Ulk1_, _etc._), phagophore nucleation (_Atg14_, _Becn1, etc._), followed by autophagosome formation (_Atg16l1_, _Atg5_, _Atg7_, _etc._), and completes with autolysosome digestion…

Background: _LRRK2_ variants (G2019S/N2081D) that increase Parkinson’s disease (PD) and Crohn’s Disease (CD) susceptibility are associated with LRRK2 kinase hyperactivity and suppress autophagy, suggesting that LRRK2 kinase inhibition, a strategy being explored for PD treatment, may also benefit CD…