Sean Spencer

Microbiome science in the gut has focused on the study of colonic, and more frequently, fecal communities. While the upper gastrointestinal tract has significantly lower bacterial density than the colon, it still harbors a dynamic microbial community…

SOCIETY: AGA This session is focused on novel strategies for developing microbiome therapeutics including the use of synthetic communities, editing microbial communities using tools such as CRISPR and the use of phages as therapeutic tools…

BACKGROUND: Loss of immune tolerance to commensal gut bacteria plays a critical role in the pathogenesis of inflammatory bowel disease (IBD). Prior studies have demonstrated that immunoglobulin (Ig) binding to the gut microbiota is altered in IBD and associated with disease activity…