Samuel Chey

INTRODUCTION: The current ‘step-down’ approach to implementing a low FODMAP diet (LFD) in which all 5 FODMAP groups are restricted presents significant practical challenges for patients, A ‘step-up’ approach has been proposed where only 1-2 FODMAP groups are initially restricted and further restric…

INTRODUCTION: A diet low in FODMAPs (LFD) is only effective in 50-60% of patients with irritable bowel syndrome (IBS) and is restrictive, time-consuming, and carries the risk of nutritional deficiencies. Therefore, there is a need for novel dietary therapies for IBS…

Background: Disaccharidases are brush border enzymes that digest disaccharides to monosaccharides for absorption across the intestinal epithelium…