Roberto de Sire

Aconitate decarboxylase 1 (ACOD1; also known as IRG-1) is the ubiquitous source of the metabolite itaconate, which dampens inflammasome activation by preventing HIF1α production of IL-1β and prevents TNF production through NRF2 activation…

Background and Aim: Inflammatory bowel disease (IBD) patients have a 2-3-fold increased risk of developing colorectal cancer…