Prashant Nighot

Background: Endoplasmic reticulum (ER) stress which undermines cellular homeostasis and survival has been linked with the pathogenesis of inflammatory bowel disease. During ER stress, induction of unfolded protein response (UPR) restores ER homeostasis and enable cell survival…

Phosphatase and tensin homolog (PTEN) is a lipid phosphatase, while its protein phosphatase activity is being suggested. Since the classical role of PTEN as a tumor suppressor is unclear in the gut, we hypothesize PTEN’s alternative function in regulating gut homeostasis…

Background: Mesenteric fat wrapping around the intestinal wall, so called ‘creeping fat’ (CF), is spatially linked with stricture formation in Crohn’s disease (CD)…

Paneth cells reside at the bottom of the crypts in the small intestine and are crucial for maintaining homeostasis of the epithelium by engendering host protection from enteric pathogens…