Petra Hirsova

Aconitate decarboxylase 1 (ACOD1; also known as IRG-1) is the ubiquitous source of the metabolite itaconate, which dampens inflammasome activation by preventing HIF1α production of IL-1β and prevents TNF production through NRF2 activation…

Introduction: The molecular mechanism by which effector CD4+ T helper (Th) cells remain activated to possibly mediate resistance to biologics and consequent refractory human inflammatory bowel disease (IBD) is not clear…