Patricia Latham

BACKGROUND: Colonic polyposis, which is a risk factor for colorectal cancer (CRC), can be driven by a pathogenic variant in a polyposis gene. However, in many cases germline genetic testing is negative, leaving the cause of the polyposis unknown…

BACKGROUND: Obesity and pro-inflammatory alterations of the gut microbiome are risk factors for gastrointestinal (GI) cancers, including liver cancer (HCC). Dysregulated TGF-β signaling through Smad3 and βII-Spectrin and loss of CEACAM1 activity are implicated in fatty liver disease…

BACKGROUND: Colon cancer is rising in younger people, with a potential link to diet and the gut microbiome. Yet, it is unclear how signaling pathways, host-microbe interactions and metabolites regulate cancer development…