Nicholas Davidson

BACKGROUND: RNA-binding motif protein 47 (RBM47) is a component of the APOBEC-1 dependent C-to-U RNA editosome required for RNA editing. However, the range of targets and functions of RBM47 in intestine is unknown…

The speakers in this session will provide insights into diverse molecular mechanisms of metaplasia, dysplasia and neoplasia across the esophagus, stomach, and colon…

BACKGROUND: Alcohol-associated hepatitis (AH) is the active inflammatory state of alcohol-associated liver disease (ALD). AH varies in severity from mild to severe with mortality rates reaching 30-50% in severe AH…

Background: Genetic variants (MTTP, TM6SF2, FABP1) that modulate hepatic steatosis are linked to increased hepatocellular carcinoma (HCC). Liver specific deletion of Mttp (Mttp-LKO) or Tms6sf2 increase fibrosis, steatosis and HCC, while Dgat2-LKO mice show decreased steatosis but not fibrosis…

BACKGROUND & AIMS: After restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) for ulcerative colitis (UC), a subset of patients develop Crohn’s-like disease of the pouch (CDP), an inflammatory condition that affects both the ileoanal pouch and extra-pouch organs including the pre-po…

BACKGROUND: C-to-U RNA editing is mediated by APOBEC1 and two RNA binding proteins (A1CF and RBM47) in WT C57 mice. We found reduced polyp burden in _Apcmin/+_ mice crossed into _Apobec1–/–_ mice, whose mechanisms are unknown…

BACKGROUND: Therapeutic approaches to impair intestinal lipid absorption are widely employed in the management of obesity and metabolic dysfunction…