Marcello Delfini

BACKGROUND: Mast cells are a major actor in the development of abdominal pain, a hallmark symptom of IBS. We recently showed that a local IgE production triggers mast cell activation leading to food-induced abdominal pain in mice…

INTRODUCTION/AIM: Delayed gastric emptying and constipation related to neurodegeneration are major complications of poorly controlled diabetes. Using scRNAseq, we identified a neuron-associated muscularis macrophage (NA-MM) population expressing F11r (CD321)…