Lanping Jiang

BACKGROUND: Through shotgun metagenomic sequencing, we identified the depletion of probiotic species_ Lactobacillus acidophilus_ in stools of mice with non-alcoholic fatty liver disease-associated hepatocellular carcinoma (NAFLD-HCC)…

BACKGROUND: _Clostridium butyricum_ is a known probiotic bacterium with anti-inflammatory activity. We found that it is depleted in patients with colorectal cancer (CRC) from multiple cohorts. Here, we examined the immunomodulatory effect of _C…

The gut microbiota is closely related to cancer patient response to immune checkpoint inhibitors (ICI). However, there are inconsistencies in species affecting ICI efficacy, whilst the role of non-bacterial microbes in immunotherapy remains elusive…

BACKGROUND: The roles of probiotics in inhibiting gastric cancer (GC) and effecting _H. pylori_ infection are largely unclear. We identified _Faecalibacterium prausnitzii_ is depleted in GC. We aimed to evaluate the antitumorigenic function and molecular mechanism of _F…

TUMOR PROMOTING ROLE OF EPIPLOIC ADIPOSE TISSUE IN COLON OF OBESE INDIVIDUALS IS MEDIATED VIA LIPID DROPLETS ASSOCIATED ADIPOSE TRIGLYCERIDE LIPASE (ATGL)