Jun Yu

BACKGROUND: Enterochromaffin cells (ECs) are specialized gastrointestinal (GI) epithelial cells that transduce luminal forces and chemicals into release of signal molecules including serotonin (5-HT) to alter GI function including mucosal ion transport…

BACKGROUND AND AIMS: Peptostreptococcus stomatis (_P. stomatis_) is an enriched bacterium in colorectal cancer (CRC) patients as compared to healthy subjects in multiple cohorts. However, the potential role of _P. stomatis_ in colorectal tumorigenesis remains obscure…

BACKGROUND AND AIMS: Peptostreptococcus stomatis (_P. stomatis_) is an enriched bacterium in colorectal cancer (CRC) patients as compared to healthy subjects in multiple cohorts. However, the potential role of _P. stomatis_ in colorectal tumorigenesis remains obscure…

BACKGROUND AND AIMS: Peptostreptococcus stomatis (_P. stomatis_) is an enriched bacterium in colorectal cancer (CRC) patients as compared to healthy subjects in multiple cohorts. However, the potential role of _P. stomatis_ in colorectal tumorigenesis remains obscure…

Background: Nonalcoholic steatohepatitis (NASH) is a major cause of liver-related morbidity, mortality, and the leading indication for liver transplant in the US. Fibrosis is the best predictor of clinical outcomes in NASH…

In this session, you will learn about the advances in microbial biotransformation of drugs and this can impact clinical outcomes and adverse events…

BACKGROUND: Immune checkpoint blockade has revolutionized cancer treatment by harnessing the patient’s native anti-tumor T cells, but most colorectal cancers do not respond, for unclear reasons…

BACKGROUND The gut microbiome is central to Crohn’s disease (CD) pathogenesis but the relative contribution of different environmental factors to disease compositional variation is unknown…

BACKGROUND: Non-alcoholic steatohepatitis (NASH), a leading cause of liver-related morbidity and mortality, is highly prevalent in people living with HIV (PLWH).1 Microbial translocation (MT) associated with hepatic inflammation and fibrosis may play a critical role in NASH pathogenesis…

BACKGROUND: Emerging evidence suggest that gut microbiota influence human health such as digestive functions and risk of sepsis…

BACKGROUND AND AIMS: Chemoresistance is a major cause of colorectal cancer (CRC) recurrence and death. The critical role of gut microbiome in the efficacy of CRC chemotherapy remains unclear…

BACKGROUND: Through shotgun metagenomic sequencing, we identified the depletion of probiotic species_ Lactobacillus acidophilus_ in stools of mice with non-alcoholic fatty liver disease-associated hepatocellular carcinoma (NAFLD-HCC)…

BACKGROUND: Through shotgun metagenomic sequencing, we identified the depletion of probiotic species_ Lactobacillus acidophilus_ in stools of mice with non-alcoholic fatty liver disease-associated hepatocellular carcinoma (NAFLD-HCC)…

BACKGROUND: Through shotgun metagenomic sequencing, we identified the depletion of probiotic species_ Lactobacillus acidophilus_ in stools of mice with non-alcoholic fatty liver disease-associated hepatocellular carcinoma (NAFLD-HCC)…

Colonoscopy surveillance intervals are based on the predicted risk of metachronous colorectal cancer (CRC) after polyp removal. Due to the presence of co-existent findings at baseline colonoscopy, risk estimation per specific polyp subtype is difficult…

_Objective_: To investigate the clinical relevance of fecal microbial dysbiosis in HCC development

BACKGROUND: The LI-RADS (Liver Reporting and Data Systems) was created to standardize reporting of CT/MR imaging for liver masses in cirrhosis patients at risk of hepatocellular carcinoma (HCC)…

BACKGROUND: The LI-RADS (Liver Reporting and Data Systems) was created to standardize reporting of CT/MR imaging for liver masses in cirrhosis patients at risk of hepatocellular carcinoma (HCC)…

BACKGROUND AND AIMS: The relationship between intratumoral fungi and the progression of colorectal cancer (CRC) is largely unclear. We aim to determine the structure of the fungal community within a neoplasia (adenoma or CRC) and its association with genetic mutation in adenoma and CRC…

BACKGROUND & AIM: About half of patients with hepatocellular carcinoma (HCC) are initially diagnosed with multi-nodule, which developed either from intrahepatic metastasis (IM) or multicentric occurrence (MO)…

BACKGROUND AND AIMS: Dysbiosis of gut virus community is associated with colorectal cancer (CRC), but viral features and genomic function remain unclear…

BACKGROUND: Metabolic dysfunction-associated steatotic liver disease (MASLD) and its more severe form metabolic dysfunction-associated steatohepatitis (MASH) are highly prevalent worldwide. However, current non-invasive diagnostic approaches for MASLD and MASH are suboptimal…

BACKGROUND The gut microbiome play an important role in Crohn’s disease (CD) pathogenesis. However, the extent to which interpersonal relations shape individual genetic makeup of the microbiome and its transmission in CD patients and their household members remains unknown…

BACKGROUND: Around 80-85% of colorectal cancer (CRC) belongs to ‘immune cold’ microsatellite stable (MSS) subtype without responsive to anti-PD-1 mAb therapy…

BACKGROUND: _Bifidobacterium catenulatum_ was reported to attenuate inflammation through modulating gut microbiota. Here, we investigated the roles of _B…

BACKGROUND: _Clostridium butyricum_ is a known probiotic bacterium with anti-inflammatory activity. We found that it is depleted in patients with colorectal cancer (CRC) from multiple cohorts. Here, we examined the immunomodulatory effect of _C…

The gut microbiota is closely related to cancer patient response to immune checkpoint inhibitors (ICI). However, there are inconsistencies in species affecting ICI efficacy, whilst the role of non-bacterial microbes in immunotherapy remains elusive…

BACKGROUND: The roles of probiotics in inhibiting gastric cancer (GC) and effecting _H. pylori_ infection are largely unclear. We identified _Faecalibacterium prausnitzii_ is depleted in GC. We aimed to evaluate the antitumorigenic function and molecular mechanism of _F…

BACKGROUND: RNA N6-methyladenoine (m6A) modification plays multifaceted roles in cancer, including tumor initiation, progression and therapy resistance. Nevertheless, the role of aberrant m6A in cancer stem cells (CSCs) remains unclear…