Jason Matthews

BACKGROUND: Perianal fistulizing complications (PFC) of Crohn’s disease (CD) are highly morbid and difficult to treat. Despite the advent of biologic medications, antibiotics remain a mainstay of PFC treatment…

BACKGROUND: Perianal Crohn’s disease (CD) induces extensive mucosal damage that is proposed to pathologically alter epithelium and mesenchyme. Here, we tested the ability of patient derived intestinal organoids to maintain the disease characteristics of perianal CD…