James Goldenring

BACKGROUND: RNA-binding motif protein 47 (RBM47) is a component of the APOBEC-1 dependent C-to-U RNA editosome required for RNA editing. However, the range of targets and functions of RBM47 in intestine is unknown…

Phosphatase and tensin homolog (PTEN) is a lipid phosphatase, while its protein phosphatase activity is being suggested. Since the classical role of PTEN as a tumor suppressor is unclear in the gut, we hypothesize PTEN’s alternative function in regulating gut homeostasis…

The speakers in this session will provide insights into diverse molecular mechanisms of metaplasia, dysplasia and neoplasia across the esophagus, stomach, and colon…

The speakers in this session will provide insights into diverse molecular mechanisms of metaplasia, dysplasia and neoplasia across the esophagus, stomach, and colon…

BACKGROUND AND AIMS: Ménétrier’s disease (MD) is a rare acquired protein-losing hypertrophic gastropathy characterized by giant gastric rugal folds, decreased acid secretion, increased gastric mucus production, and hypoalbuminemia due to protein loss in the gastric mucosa…

BACKGROUND AND AIMS: Ménétrier’s disease (MD) is a rare acquired protein-losing hypertrophic gastropathy characterized by giant gastric rugal folds, decreased acid secretion, increased gastric mucus production, and hypoalbuminemia due to protein loss in the gastric mucosa…

SOCIETY: AGA

Isthmic progenitor cells, tissue-specific stem cells in the stomach corpus, maintain mucosal homeostasis by balancing between proliferation and differentiation to gastric epithelial cell lineages. The progenitor cells rapidly adopt an active state in response to mucosal injury…

Background: Ras pathway activation in gastric chief cells induces a sequential cascade from normal to metaplasia and dysplasia, a key stage of developing gastric cancer…