Hajar Hazime

The autonomic nervous system, with its two branches the parasympathetic and the sympathetic, plays a pivotal role in the regulation of many physiological responses to maintain metabolic homeostasis in variable target tissues…

BACKGROUND A defective gastrointestinal epithelial tight junction (TJ) barrier has been implicated as a key pathogenic factor in inflammatory bowel diseases (IBD) and other gut inflammatory conditions…

We have shown that Activin A (activin), a TGF-β superfamily member, has pro-metastatic effects on colon cancer cells…

BACKGROUND: Inflammatory bowel diseases (IBD) are characterized by dysbiosis, defects in epithelial barrier function, and increased redox stress…

BACKGROUND: Crohn’s disease (CD) is characterized by chronic intestinal inflammation and dysbiosis. Diet plays a pivotal role in the development of CD and recent studies highlight the feasibility and effectiveness of specific diet interventions in improving symptoms…

BACKGROUND: Ulcerative colitis (UC) is associated with dysbiosis and an increased risk of colon cancer over time. Non-invasive methods of identifying UC patients at risk of developing CAC do not exist…

SOCIETY: AGA While it is intuitive that inflammation of the bowel can be affected positively and negatively by diet, it is only recently that the underpinnings of diet on inflammatory bowel disease have been explored…

MACROPHAGE LRRK2 HYPERACTIVITY IMPAIRS AUTOPHAGY AND INDUCES PANETH CELL DYSFUNCTION AND INTESTINAL INFLAMMATION