Gregory Yochum
Appearances
- DateMay 7, 2023Background: Resolution of intestinal inflammation requires well-tuned communication between the immune compartment and the epithelium, carried out primarily via secreted mediators. The expression of these mediators is predominantly regulated by the transcription factor NF-κB…
- DateMay 6, 2023BACKGROUND The prevalence of chronic liver disease is increasing but it remains underdiagnosed, with frequent late presentation. Development in early adulthood is likely to associate with higher lifetime cirrhosis risk but early identification of asymptomatic patients can prove challenging…
- DateMay 18, 2024INTRODUCTION: Crohn’s Disease (CD), one of the major forms of inflammatory bowel disease (IBD), involves genetic and environmental factors and currently has no cure. Fibrosis is strongly associated with CD, has no pharmacological treatment, and often requires surgical intervention…
- DateMay 18, 2024Background: Primary sclerosing cholangitis (PSC) is a progressive choleostatic disease and up to 80% of patients also have ulcerative colitis (PSC-UC). This presents a clinical challenge owing to difficulty in diagnosis and increased risk for developing cancer…
- DateMay 21, 2024BACKGROUND: Ulcerative colitis (UC) is a chronic multifactorial disease with limited management options. Hyperactivation of Janus kinase (JAK) signaling is implicated in the pathogenesis of UC…