George Cholankeril

BACKGROUND AND AIMS: Screening tools are needed for early detection of NAFLD-fibrosis. We aimed to identify risk factors for NAFLD-fibrosis in the multiethnic population of the U.S. and thus accelerate development of equitable screening tools…

BACKGROUND The prevalence of chronic liver disease is increasing but it remains underdiagnosed, with frequent late presentation. Development in early adulthood is likely to associate with higher lifetime cirrhosis risk but early identification of asymptomatic patients can prove challenging…

BACKGROUND: Primary sclerosing cholangitis (PSC) is a progressive, cholestatic liver disease without medical cure, that confers a significantly elevated risk of malignancy, acute cholangitis and cirrhosis. Approximately 2-7% of patients with inflammatory bowel disease (IBD) will develop PSC…

BACKGROUND: Patients with MASLD and diabetes have an increased risk of cirrhosis and hepatocellular cancer (HCC). Recent studies show that glucagon-like peptide-1 (GLP-1) agonists, such as semaglutide, are effective in improving liver inflammation in MASLD…

BACKGROUND: Current understanding of the rates and trajectories of progression to cirrhosis complications is derived from outdated data. We examined the progression patterns of cirrhosis and their implications, focusing on the different outcomes of prolonged illness _vs_…