Society: ASGE

Background: GI endoscopy procedures are critical for the screening, diagnosis, and treatment of a variety of patient signs/symptoms. However, similar to other medical disciplines, they are a source of environmental waste generation and energy consumption in form of plastic, sharps, personal protective equipment (PPE), cleaning supplies and energy.

Methods: We prospectively collected data on total waste generation of a single large academic endoscopy unit over a 2-month period (May-June 2022). During this time period, detailed data on items used for every patient were collected from the point of patient entry to the endoscopy unit until discharge including procedure type, accessories used, IV tubing, number of biopsy jars, linen, PPE usage etc. In addition, reprocessing related waste generation for each procedure and energy utilization for the unit (endoscopy equipment, lights, computers etc.) for each day were also collected. The waste generated was stratified into biohazardous, non-biohazardous, or potentially recyclable items (to determine opportunities to improve/maximize recycling of waste). No patient information was collected, and the study was approved by the IRB.

Results: We prospectively analyzed waste generation for 450 consecutive procedures over a 2-month period. The total waste generated during this time period was 1398.6 kg - 61.6% directly going to landfill, 33.3% biohazard waste and 5.1% sharps. The average per procedure waste directly going to landfill was 2.19 kg which approximates to 9,189 kg for an entire year or 219 kg/100 procedures. 20% of the total waste generated was potentially recyclable (i.e. plastic CO₂ tubing, O₂ connector, syringes etc.). This could reduce total waste going to landfill by 8.6 kg per day (2,580 kg per year) or 61 kg per 100 procedures (Figure 1). Endoscope reprocessing generated 194 gallons of liquid waste (=735.26 kg.) per day or 1385 gallons per 100 procedures. In total, the annual waste generation approximated the size of 2 football fields. Finally, energy consumption in the endoscopy unit was 277.1 kW hour energy per day (=8.2 gallons of gasoline) or ~1980 kW hour per 100 procedures. Energy consumption for 100 procedure amounts to 1200 miles of distance (i.e. Seattle to San Diego) traveled by an average fuel efficiency car.

Conclusion: On average, every 100 routine GI endoscopy procedures (EGD/colonoscopy) are associated with 218 kg. landfill waste generation, and 2000kW hour energy consumption. Potentially recyclable materials account for 20% of the total waste – this can be a simple initial step to reduce waste going to landfill. These data could serve as an actionable model for health-systems to reduce total waste generation, landfill, and water waste towards environmentally sustainable endoscopy units.

Figure 1. Average daily waste distribution in the endoscopy unit

Figure 1. Average daily waste distribution in the endoscopy unit

Table 1. Total waste production and energy per day and per 100 procedures

Table 1. Total waste production and energy per day and per 100 procedures

Introduction
Adequate bowel preparation is essential for optimal visualization during a colonoscopy, yet inadequate bowel preparation (IBP) remains common despite preprocedural interventions and adherence to preparation protocols. Poor bowel preparation often leads to suboptimal or canceled procedures, causing frustration and lost opportunity time for patients and endoscopists alike. An FDA-approved, 3rd generation over-the-scope intraprocedural cleansing system could serve as a solution for IBP.

Methods
We performed a retrospective study at a Veteran Affairs (VA) hospital over a 12-month period comparing the adequacy of bowel preparation at the time of colonoscopy in the six months before and after the implementation of an intraprocedural cleansing system. IBP was defined as a Boston Bowel Preparation Score (BBPS) of < 6 or a bowel preparation described as poor or inadequate per the Aronchick scale.

Results
We studied a total of 2,367 colonoscopies over a 12-month period from 10/2021 to 9/2022, implementing the intraprocedural cleansing system in 4/2022. There were 1,198 pre-implementation cases from 10/2021-3/2022 and 1,169 post-implementation cases from 4/2022-9/2022. The cleansing system was utilized in 46 cases with an increase in use over time. The IBP rate decreased after the cleansing system was implemented with a pre-implementation IBP rate of 9.3% (111/1,198 cases) and a post-implementation IBP rate of 5.9% (69/1,169 cases) (Figure 1). Further analysis of the successful cases using the cleansing system (N=36) revealed a substantive increase in the adequacy of bowel preparation with the average BBPS improving from 4.8 to 8.7. Unsuccessful device cases were almost exclusively related to patient intolerance of sedation or anatomical reasons that precluded even a device-free colonoscope from passing.

Conclusion
This is the first study to compare the rates of inadequate bowel preparation before and after the implementation of an intraprocedural cleansing system. The rates of IBP decreased significantly following the implementation of the intraprocedural cleansing system. The use of this device is both feasible and results in improved bowel preparation rates. Better bowel preparation at the time of colonoscopy may have an important impact in terms of improved examination quality and patient experience, longer duration of surveillance colonoscopy intervals, and decreased suboptimal or canceled procedures with better resource utilization.

<b>Figure 1</b>: The monthly rate of inadequate bowel preparation before <i>(blue)</i> and after (<i>orange)</i> implementation of the intraprocedural cleansing system. Overall, we saw a decrease in the average rate of inadequate bowel preparation from 9.3% in the six months preceding the implementation of the device to 5.9% in the six months following the implementation of the device.

Figure 1: The monthly rate of inadequate bowel preparation before (blue) and after (orange) implementation of the intraprocedural cleansing system. Overall, we saw a decrease in the average rate of inadequate bowel preparation from 9.3% in the six months preceding the implementation of the device to 5.9% in the six months following the implementation of the device.

Background: Apart from adequate bowel preparation, colonic spasm is one of the significant problems that impair visualization during colonoscopy, and might affects the adenoma detection rate (ADR). When glucagon is not available, hyoscine was used to reduce colonic spasms with concerning adverse effects. In vitro research showed peppermint oil (PO) to be effective in relaxing colonic smooth muscle. Previous studies revealed the heterogeneous outcome of intraluminal PO on colonic spasms and ADR.
Aim: To investigate the efficacy of intraluminal PO on colonic peristalsis, ADR, polyp detection rate (PDR), adenoma per positive participants (APP), and safety.
Study design: A prospective, randomized, double-blinded, placebo-controlled trial was conducted. Of 408 patients, randomization to receive either a 50 ml solution of 1.6% PO plus simethicone (PO group) or simethicone alone (placebo group). All patients undergoing colonoscopy under propofol and/or fentanyl sedation supervised by an anesthesiologist. After the cecum was reached, the baseline colonic peristalsis score (0-3) was recorded. Then, the solution was infused through the scope channel over the cecum. The peristalsis score was graded again 30 seconds later and at the end of the procedure. An additional dose of solution or intravenous hyoscine can be requested if there is an inadequate response. Room air insufflation was used during scope withdrawal. Outcomes including ADR, APP, improvement of colonic peristalsis after spraying, procedure time, hemodynamic change, and patients’ symptoms after colonoscopy was assessed.
Results: The mean age was 60, and 67% were female. The patient’s characteristics were comparable among the two groups, and most of them achieved adequate bowel preparation (Table 1). Overall, ADR was 41.2%, and no difference was observed among the two groups (42.2% in PO vs. 40.2% in placebo, p=0.69). PDR (56.4% in PO vs. 55.9% in placebo, p=0.92) and APP (2.36 in PO vs. 2.21 in placebo, p= 0.23) were also no significant difference (Fig1a). The at least 1-grade improvement of peristalsis after the 1^st spray was comparable between the two groups (Fig 1b). Interestingly, the overall mild or no peristalsis (score 0-1) was significantly higher in the placebo group (83.8% vs. 77.7%, p=0.006). Hyoscine was infrequently used, and no significant adverse events occurred in both group.
Conclusion: This randomized, double-blinded study failed to demonstrate the significant benefit of intraluminal PO in reducing colonic peristalsis or increasing ADR. However, overall peristalsis was gentle, and ADR was adequate. Further study to evaluate the appropriate dose and administration of PO is warranted.

Table 1. Patient’s characteristics and outcomes

Table 1. Patient’s characteristics and outcomes

INTRODUCTION
Different virtual chromoendoscopy techniques to enhance imaging have shown controversial results in increasing Adenoma Detection Rate (ADR) during colonoscopy. A new imaging modality, Texture and Color Enhancing Imaging (TXI, Exera X1, Olympus, Japan) was recently proposed as a substitute to standard high definition white light (WLI) colonoscopy, but no study has assessed its efficacy in a clinical trial. We performed an international, multicenter randomized trial to assess the efficacy of TXI in detection of colorectal neoplasia.
METHODS
We enrolled consecutive patients >40 years old undergoing screening, surveillance or diagnostic colonoscopies at 5 centers (Italy, Germany, Japan) from September 2021 through May 2022. Patients were randomly assigned (1:1) to groups undergoing colonoscopies with TXI or WLI (controls). The primary outcome was adenoma detection rate (ADR, the percentage of patients with at least 1 histologically proven adenoma or carcinoma). Secondary outcomes were adenomas detected per colonoscopy (APC), and withdrawal time. Adjusted Odds Ratios (OR) for age, sex and colonoscopy indication were calculated.
RESULTS
We enrolled a total 747 patients, [11 expert endoscopists (mean age: 62.9±9.08 years)]. ADR was statistically significantly higher in the TXI group (221/375, 58.9%) than in the WLI group (159/372, 42.7%; adjusted RR: 1.35; 95% CI:1.17 to 1,56), as well as APC (1.36 ± 1.79 vs 0.89 ± 1.35; incident rate ratio, 1.53 [95% CI:1.25; 1.88]). No statistically significant difference in withdrawal time (TXI: 7.76±2.09 minutes vs WLI: 8.07 ±1.78; p = ns) was observed. No difference between TXI and control was observed in term of adequate (Boston Bowel Preparation Scale >2 in all colonic segments) cleansing (363/375, 96.8% vs 351/372, 94.4%) and cecal intubation rate (366/375 subjects, 97.6% vs 365/372, 98.1%).
CONCLUSIONS
In a multicenter randomized trial, we found that TXI increased ADR and APC in a non selected population of patients undergoing colonoscopy for various indications. TXI was associated with increased detection of polyps <10mm in size, both in the proximal and in the distal colon. The use of TXI during colonoscopy may be of benefit to increase colonoscopy quality indicators.

Fabrizio Cereatti

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