David Cohen

Colorectal cancer (CRC) incidence and mortality have been decreasing in those who are 50 and older (late onset) over the last 30 years, however, the incidence of CRC in people less than 50 years old (early-onset) has increased from 8.6 to 12.9 per 100,00 from 1992 to 2018…

Colorectal cancer (CRC) shows a dramatic drop in the five-year survival rate from 90% for localized tumors to 14% for metastatic CRC (mCRC). Our lab has identified LIN28B, an RNA-binding protein overexpressed in 30% of CRCs, as an oncogene that promotes CRC metastasis…

MODELING THE TUMOR MICROENVIRONMENT OF EARLY AND LATE ONSET COLORECTAL CANCER USING PATIENT-DERIVED ORGANOIDS