Ana Carolina Dantas Machado

The molecular circadian clock helps optimize host physiology to the environment by influencing the timing and coordination of metabolic processes. Host-microbe interactions also play an important role in determining metabolic responses to environmental challenges…

BACKGROUND: There are few interventions that, when introduced at an advanced age in mammals, are known to improve healthspan. Caloric restriction and time-restricted feeding (TRF) improve healthspan, with up to 35% extension in lifespan when used with circadian alignment…