Alan Saghatelian

BACKGROUND: There are few interventions that, when introduced at an advanced age in mammals, are known to improve healthspan. Caloric restriction and time-restricted feeding (TRF) improve healthspan, with up to 35% extension in lifespan when used with circadian alignment…

BACKGROUND: Obstructive sleep apnea (OSA) independently worsens atherosclerosis. Yet, the mechanisms through which OSA or its characteristic components, intermittent hypoxia and hypercapnia (IHC), increase atherosclerosis risk remain unclear…